Prostate cancer types ppt
- Asap prostate pathology
- Fiú és prosztatitis
A normál epitélium metapláziáját lapos epitéliummá a dohányzás okozta krónikus irritáció váltja ki. A neoplázia következő lépése.
A normál cervikális lapos epitélium diszplasztikus lapos epitéliummá válik. A diszplázia kóros növekedésű epitélium, de megfordítható folyamat.
A sejtes transzformációt neoplázia potenciálisan visszafordítható folyamatok előzik meg: Metaplázia: a normál epitélium kicserélődése egy másfajta epitéliummá. A kiváltó ok megszűnésével visszafordítható.
Diszplázia: az epitélium rendezetlen növekedése és érése, ami szintén visszafordítható a kiváltó ok megszüntetésekor. Shown here are the first 10, and best-characterized, CT antigens, the number of genes that encode them, and the chromosomal location of the genes. Genes encoding 17 of the 38 CT antigens are on the X chromosome; the others are distributed between 11 autosomes, none of which has genes for more than three CT antigens. Hogyan aktiválódnak a CD8 T-sejtek?
TUMOR IMMUNOLÓGIA.
The antibody is conjugated to horseradish peroxidase, which produces a brown stain wherever the antibody binds. The stain and HLA class I molecules are not seen on the tumor mass but are restricted to lymphocytes infiltrating the tumor and tissue stromal cells. Photograph courtesy of G. Variant tumor cells can evade this response by making a protease that cleaves MIC from the cell surface.
Diffúz nagysejtes B sejt lymphoma Eddig nem volt diff. Some chromosomal alterations can already be recognized in pre-cancerous lesions. However, chromosomal alterations are most frequent in tumor metastases.
This has two effects to the tumor's advantage. TGFβ és T-reg. Lancet Oncology 26 Melanóma regressziója terápiás vakcinációt követően.
Dendritic cells from an organ graft stimulate both the direct and indirect pathways of allorecognition when they travel from the graft to the draining lymphoid tissue. The right-hand panel shows how the death of the same antigen-presenting cell produces membrane vesicles containing the allogeneic HLA class I and II allotypes, which are then endocytosed by the recipient's dendritic cells recipient DC.
Peptides derived from the donor's HLA molecules yellow can then be presented by the recipient's HLA molecules orange to peptide-specific T cells indirect allorecognition. The cells from the person who serves as the stimulator yellow are first irradiated to prevent their proliferation. Then they are mixed with the cells from the other person who serves as the responder blue and cultured for five days top panel.
In the culture, responder lymphocytes are stimulated by allogeneic HLA class I and II molecules expressed by the stimulator's monocytes and the dendritic cells that differentiate from the monocytes.
Tumorbiológia dr. Tőkés Anna-Mária Semmelweis Egyetem II
The stimulated lymphocytes proliferate and differentiate into effector cells. Five days after mixing, the culture is assessed for T-cell proliferation bottom left panelwhich is due to CD4 T cells recognizing HLA class II differences, and for cytotoxic T cells bottom right panel produced in response to HLA class I differences.
Donor dendritic cells in the graft in this case a kidney carry complexes of donor HLA molecules and donor peptides on their surfaces. The dendritic cells are carried to a draining secondary prostate cancer types ppt organ the spleen is illustrated herewhere they move to the T-cell areas.
Genomika klinikai alkalmazásai 1.
Here, they activate the recipient's T lymphocytes whose receptors can bind specifically to the complexes of allogeneic donor HLA both class I and class II in combination with donor peptides. After activation, the effector T cells travel in the blood to the grafted organ, where they attack cells that display the peptide:HLA-molecule complexes for which the T cells are specific.
Limfociták és plazmasejtek a vese tubulusok körül. Az immunszuppresszió CSA felfüggesztésekor léphet fel.
Érfal vastagodáshoz és a lumen szűküléséhez vezet. Left-hand panel: chronic rejection is initiated by prostate cancer types ppt interaction of anti-HLA class I alloantibodies with blood vessels of the transplanted organ. Antibodies bound to endothelial cells E recruit Fc receptor-bearing monocytes and neutrophils.
EL, internal elastic lamina; SMC, smooth muscle cells. Right-hand panel: accumulating damage leads to EL thickening and to infiltration of the underlying intimas with SMCs, macrophages Mgranulocytes Galloreactive T cells Tand antibodies.
- A prosztata adenoma diagnózisa
- Prostata agrandada psa alto
The net effect is to narrow the lumen of the blood vessel and create a chronic inflammation that intensifies tissue remodeling. Eventually the vessel becomes obstructed, ischemic, and fibrotic. A vese artériák a krónikus vaszkuláris rejekció miatt megvastagodtak és fibrotikusak.
Types of Prostate Cancer - Dr Scott B. Sellinger
Az akut kilökődéssel szemben nem kezelhető, hónapokkal, évekkel az átültetés után jelenik meg. Vese intersticiális fibrózis krónikus vaszkuláris kilökődést követően 43 Indirekt prezentáció DC B Allo-ellenanyagok krónikus kilökődést okoznak amit az indirekt útvonal közvetít DC B The processing and presentation of allogeneic HLA class I by a dendritic cell DC of the recipient is shown.
The dendritic cell activates helper CD4 T cells, which in turn activate B cells that have bound and internalized allogeneic donor HLA molecules. Shown here is a cognate interaction that leads to A prosztatitis fáj a vese production of an anti-HLA class I antibody.
