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Uterine myometria and spontaneous leiomyomas from the Eker rat, which carries a germ-line mutation in the tuberous sclerosis complex-2 Tsc2 tumor suppressor gene prostate cancer treatment wiki, were analyzed for genetic defects in and expression of the Tsc2 and HMGA proteins [2].

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Unregulated proliferation of mesenchymal cells in leiomyomaslipomashamartomas,and other diseases has been linked to the high mobility group HMGA family of DNA architectural proteins [2]. HMGA proteins are thought to be causally involved in the progression of different diseases, including benign and malignant tumors, obesityarteriosclerosis, and restenosis [4].

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Fluorescence recovery after photobleaching experiments revealed that HMGA and HMGB proteins are extremely dynamic in the nucleus, indicating that they bind chromatin only transiently before moving on to the next site, thereby continuously scanning the genome for targets [7]. To better understand the role of HMGA and to establish whether its up-regulated expression is sufficient to induce the transformed phenotypewe generated PC Cl 3 cells that overexpress the protein [1].

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Because the phosphorylation of the HMGA proteins attenuates binding affinity and reduces the extent of contacts between the DNA and protein, it is likely that this process mirrors the dynamics and diversity of regulatory processes in chromatin [8]. Chromosomal aberrations affecting the HMGA genes may therefore influence their expression by an altered stability of the truncated transcripts as a result of the cytogenetic aberrations [9].

HMGA proteins in malignant peripheral nerve sheath tumor and synovial sarcoma : preferential expression of HMGA2 in malignant peripheral nerve sheath tumor [11].

Chemotherapy in the general sense is a healing process in which a group of disease-causing microorganisms or cells can be killed by introducing chemicals into the body. Its best-known field of application is therapy for the removal of malignant cancers within oncology, but in pharmacology the term often also refers to a definable group of antibiotics antibacterial chemotherapy.

The Prostate cancer treatment wiki ectopic expression in HMGA -negative Dunning G cells does not significantly alter their growth ability, suggesting that, although HMGA expression is necessary for the progression of neoplastic transformation in several cellular models, in these cells it is not sufficient [12].

Very soon after their original identification in HeLa cells inHMGA proteins appeared as interesting cancer-related molecules [13].

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Associations of MEGLUTOL with other chemical compounds Effects of 3-hydroxymethylglutaric acid on plasma and low-density lipoprotein cholesterol levels in familial hypercholesterolemia [14].

Age-dependent excretion of 3-hydroxymethylglutaric acid HMG and ketone bodies in the urine of full-term and pre-term newborns [16]. Urinary levels of 3-hydroxymethylglutaric acid HMG were measured by gas-liquid chromatography GLC after an extraction with tetrahydrofuran in normal rats, streptozotocin -diabetic rats and starved rats [17].

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Effect in vitro of 3-hydroxymethylglutaric acid on the synthesis of mevalonate and its precursors [18]. What information is available, however, indicates that all three major families of mammalian HMG proteins i. Northern blot results show that the expression of HMGA gene is much higher in organs undergoing active cell proliferation [23].

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Previous reports of patients with 3-hydroxymethylglutaric aciduria have described the occurrence of di-trimethylsilyl TMS and tri-TMS derivatives of 3-hydroxymethylglutaric acid on analysis using gas chromatography and mass spectrometry, leading to difficulty in quantification and ambiguity in diagnosis [24].